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Committee Opinion No. 571: Solutions for surgical preparation of the vagina.

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More than twice as many women in the higher strength group reported vaginal burning or requested cessation compared with the lower strength group Povidone-Iodine Povidone-iodine is the most commonly used antiseptic for surgical preparation of the vagina in the United States. Solutions for Surgical Preparation of the Vagina. As with iodine-based preparations, serious topical reactions and anaphylaxis occur rarely. Although chlorhexidine gluconate has been safely used for the past 40 years on skin and mucous membranes, there are case reports of serious adverse events including, anaphylaxis and epithelial desquamation associated with vaginal use of chlorhexidine gluconate 12,

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